Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Position:В hg38 chr14:95,090,498-95,133,458 Size:В 42,961 Coding Exon Count:В 26Д¬omments and Description Text from UniProtKBДESCRIPTION: RecName: Full=Endoribonuclease Dicer EC=3.1.26.- AltName: Full=Helicase with RNase motif Short=Helicase MOI ДЇUNCTION: Required for formation of the RNA induced silencing complex (RISC). Alternative splicing results in multiple transcript variants. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. RefSeq Summary (NM_177438): This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. Also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre- miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2.

Human Gene DICER1 (ENST00000393063.6) from GENCODE V39Дescription: Required for formation of the RNA induced silencing complex (RISC).

Dendrite blastoma